Description
Generic name: ceftizoxime sodium
Dosage form: Injection
Drug class: Third generation cephalosporins
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The usual adult dosage is 1 or 2 grams of Safezox (ceftizoxime injection) in Protectplastic container every 8 to 12 hours. Proper dosage and route of administration should be determined by the condition of the patient, severity of the infection, and susceptibility of the causative organisms.
Because of the serious nature of urinary tract infections due to P. aeruginosa and because many strains of Pseudomonas species are only moderately susceptible to Safezox, higher dosage is recommended. Other therapy should be instituted if the response is not prompt.
A single, 1 gram IM dose is the usual dose for treatment of uncomplicated gonorrhea.
The IV route may be preferable for patients with bacterial septicemia, localized parenchymal abscesses (such as intra¬abdominal abscess), peritonitis, or other severe or life¬threatening infections.
In those with normal renal function, the IV dosage for such infections is 2 to 12 grams of Safezox (ceftizoxime injection) daily. In conditions such as bacterial septicemia, 6 to 12 grams/day may be given initially by the IV route for several days, and the dosage may then be gradually reduced according to clinical response and laboratory findings.
Pediatric Dosage Schedule
Unit Dose Frequency
6 months or older 50 mg/kg q6-8h
Dosage may be increased to a total daily dose of 200 mg/kg (not to exceed the maximum adult dose for serious infection).
