Ceftizoxime+sulbactam belongs to the group of medicines called antibiotics. It is used to treat a wide
variety of bacterial infections in the body. A bacterial infection is a condition in which harmful bacteria
grow in the body and cause infection.
Ceftizoxime+sulbactam contains Ceftizoxime (third-generation cephalosporin antibiotic) and
Sulbactam (beta-lactamase inhibitor). It works by inhibiting the synthesis of the bacterial cell wall (a
protective covering) that is necessary for their survival. This causes damage to the bacterial cell wall
and eventually leads to the death of the bacterial cell. Sulbactam works by decreasing bacterial
resistance and enhancing the activity of Ceftizoxime against the bacteria. Together,
Ceftizoxime+sulbactam helps treat bacterial infections.
Ceftizoxime+sulbactam will be administered by a healthcare professional; do not self-administer. In
some cases, Ceftizoxime+sulbactam may cause injection site reactions, diarrhoea, nausea,
vomiting, headache, rash, stomach upset, and indigestion. Most of these side effects of
Ceftizoxime+sulbactam do not require medical attention and gradually resolve over time. However, if
the side effects are persistent, reach out to your doctor.
Let your doctor know about your medical and medication history to avoid the occurrence of potential
interactions. Ceftizoxime+sulbactam should only be given during pregnancy when the need has
been established. Hence, inform your doctor if you are pregnant, suspect you are pregnant or plan to
have a baby; your doctor will weigh the benefits of Ceftizoxime+sulbactam therapy against the risk to
your baby. Breastfeeding should be avoided unless instructed by the doctor. Consumption of alcohol
should be avoided while on treatment with Ceftizoxime+sulbactam.
Uses of Ceftizoxime+sulbactam
Ceftizoxime+sulbactam is used in the treatment of various bacterial infections by combining the
antibacterial actions of Ceftriaxone and Sulbactam. The detailed uses of Ceftizoxime+sulbactam are
as follows:
• Treats respiratory tract infections: Ceftizoxime+sulbactam acts effective against lung and sinus
infections including pneumonia, bronchitis, and sinusitis.
• Manages ENT infections: Ceftizoxime+sulbactam is used for bacterial infections of the ear and
throat such as otitis media and tonsillitis.
• Effective in urinary tract infections: Ceftizoxime+sulbactam treats bladder and kidney infections
caused by susceptible bacteria.
• Controls skin and soft tissue infections: It is indicated for cellulitis, wound infections, and other soft
tissue infections.
Medicinal Benefits
Ceftizoxime+sulbactam contains Ceftizoxime and Sulbactam. Ceftizoxime is a third-generation
cephalosporin antibiotic, and Sulbactam is a beta-lactamase inhibitor. It acts by blocking the
synthesis of the bacterial cell wall, which is required for their survival. This damages the bacterial cell
wall and eventually kills the bacterial cell. Sulbactam reduces bacterial resistance while increasing
the activity of Ceftizoxime against bacteria. Together, Ceftizoxime+sulbactam helps to treat bacterial
infections.
Directions for Use
• Follow your doctor's instructions on the dosage and timing of this medication. •
Ceftizoxime+sulbactam will be administered by a healthcare professional. • Do not self-administer it.
Storage
Store in a cool and dry place away from sunlight
Side Effects of Ceftizoxime+sulbactam
Injection site reactions
Diarrhoea
Nausea
Vomiting
Headache
Rash
Stomach upset
Indigestion
Drug Warnings
Before taking the Ceftizoxime+sulbactam, inform your doctor about all of your medical
problems, sensitivities, and drugs. If you are pregnant or breastfeeding, check with your
doctor before taking Ceftizoxime+sulbactam. For effective outcomes, it is recommended
that you complete the entire course of Ceftizoxime+sulbactam as prescribed by your
doctor. If you are received or scheduled for immunizations, inform your doctor.
Ceftizoxime+sulbactam should be used cautiously in people with Clostridium difficile-
associated diarrhoea.
Drug Interactions
Drug-Drug Interaction: Ceftizoxime+sulbactam may interact
with immunosuppressive medications (e.g. Mycophenolate mofetil, Mycophenolic acid)
and certain vaccinations (BCG vaccine, Cholera vaccine live, Typhoid vaccine live).
Drug-Food Interaction: Alcohol consumption should be avoided.
Drug-Disease Interaction: Ceftizoxime+sulbactam may interact with certain disease
conditions, including colitis (inflammation in your colon), renal dysfunction, renal
impairment, dialysis, liver disease, and seizure disorders. So, inform your doctor about
your medical conditions before taking Ceftizoxime+sulbactam.
Drug-Drug Interactions Checker List:
MYCOPHENOLATE MOFETIL
MYCOPHENOLIC ACID
BCG VACCINE
CHOLERA VACCINE LIVE
TYPHOID VACCINE LIVE
Safety Advice
ALCOHOL
NOT APPLICABLE
Avoid consuming alcohol while taking Ceftizoxime+sulbactam.
PREGNANCY
CAUTION
Ceftizoxime+sulbactam should only be given during pregnancy when the need has been
established. Therefore, please inform your doctor if you are pregnant or planning for
pregnancy; your doctor will weigh the benefits and potential risks before prescribing this
medicine.
BREAST FEEDING
CAUTION
Inform the doctor if you are breastfeeding. A decision should be made whether to
discontinue nursing or the medicine, taking into account the importance of the medicine to
the mother.
DRIVING
SAFE IF PRESCRIBED
Ceftizoxime+sulbactam is unlikely to affect your ability to drive.
LIVER
CAUTION
Caution should be exercised while using Ceftizoxime+sulbactam in patients with liver
disease. Inform your doctor before receiving Ceftizoxime+sulbactam if you have a history of
liver diseases. Your doctor will prescribe only if the benefits outweigh the risks.
KIDNEY
CAUTION
Caution should be exercised while using Ceftizoxime+sulbactam in patients with kidney
disease. Inform your doctor before receiving Ceftizoxime+sulbactam if you have a history of
kidney diseases. Your doctor will prescribe only if the benefits outweigh the risks.
CHILDREN
CAUTION
Limited information is available for the use of Ceftizoxime+sulbactam in children. Hence, it
will be administered to the children only if needed.
Habit Forming
No
Diet & Lifestyle Advise
Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-
associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut,
kombucha, and kimchi can help restore the intestine's good bacteria.
Include more fibre-enriched food in your diet, as it can be easily digested by gut
bacteria, which helps stimulate their growth. Whole grains like whole-grain bread
and brown rice should be included in your diet.
Avoid intake of alcoholic beverages with Ceftizoxime+sulbactam as it can make
you dehydrated and may affect your sleep. This can make it harder for your body
to aid Ceftizoxime+sulbactam in fighting off infections.
Patients Concern
Disease/Condition Glossary
Bacterial infections: A bacterial infection is when harmful bacteria enter, multiply, and infect the
body. Infectious or harmful bacteria can make you sick and reproduce quickly in the body. These
harmful bacteria produce toxins, which can damage tissue and make you sick. It can target any body
part and multiply very quickly. When infected with bacteria, you can experience generalized
symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection.
However, people with weak immune systems or taking immunosuppressive medicine are more
prone to bacterial infection.
FAQs
What is the use of Ceftizoxime+sulbactam?
Ceftizoxime+sulbactam is used to treat Bacterial infections.
How does Ceftizoxime+sulbactam work?
Ceftizoxime+sulbactam contains Ceftizoxime and Sulbactam. Ceftizoxime works by
preventing the formation of bacterial cell covering, which is necessary for their survival.
Thereby killing the bacteria. Sulbactam works by decreasing bacterial resistance and
enhancing the activity of Ceftizoxime against the bacteria. Thus, Ceftizoxime+sulbactam
helps to treat bacterial infections.
Does Ceftizoxime+sulbactam cause diarrhoea?
Ceftizoxime+sulbactam may cause Clostridium difficile-associated diarrhoea (CDAD).
Antibiotic treatment alters the normal flora, leading to overgrowth of Clostridium difficile,
which causes diarrhoea. Drink lots of fluids and eat non-spicy food if you experience
diarrhoea. If you find blood in your stools (tarry stools) or if you experience prolonged
diarrhoea with abdominal pain, stop taking Ceftizoxime+sulbactam and consult your
doctor. Do not take anti-diarrheal medicine on your own.
What if I do not get better after using Ceftizoxime+sulbactam?
Inform your doctor if you do not feel better even after finishing the full course of
treatment. If the symptoms worsen while using this medicine, consult your doctor.
How long does Ceftizoxime+sulbactam take to work?
Usually, Ceftizoxime+sulbactam starts working soon after taking it. However, it may take
a few days to kill all the harmful bacteria and make
